Publications

All published data will be available in open data sharing platforms

Flexible ensheathment of axons enables myelination of complex CNS networks

Cody L. Call, Sarah A. Neely, Jason J. Early, Owen G. James, Lida Zoupi, Anna C. Williams, Yu Kang T. Xu, Siddharthan Chandran, David A. Lyons, Kelly R. Monk & Dwight E. Bergles – (2026) Nature  (doi: https://doi.org/10.1038/s41586-026-10312-1)

Reduced inhibition, bursting, and accelerated oscillations drive early hippocampal hyperactivity in Alzheimer’s disease in vivo

Soraya Meftah, Sungmin Kang, Mingshan Liu, Xingran Wang, Ada Nursel Topçu, Maialen Martin Abad, Áron Kőszeghy, Long Wan, Conor Mullin, Lida Zoupi & Jian Gan – (2026) Communications Biology & bioRxiv  (doi: 10.1038/s42003-026-09918-y)

Selective Derailment of Microglial Specialisation Drives a Childhood Dementia

David Munro, Michael Sewell, Sarah Choi, Vanessza Fentor, Stefan Szymkowiak, Jack Barrington, Gaia Brezzo, Colin L. Crawford, Mila Redzic, Dana Straus, Samuel Heczko, Aisling Kenny, Xiangning Li, Arlo Simmerman, Nela Fialova, Conor McQuaid, Karina McDade, Denise Stuart, Vicky Walczak-Gillies, Olivia M. Rifai, Jenna M. Gregory, Xin He, Owen R. Dando, Anirudh Patir, Takahiro Masuda, Marco Prinz, Calum C. Bain, Lida Zoupi, Axel Montagne, Colin Smith, Geneviève Bernard, Michael J.D. Daniels, Josef Priller & Barry W. McColl – (2026) Under review in Cell Press  (doi: 10.2139/ssrn.6477998)

Assessing oligodendrocyte and myelin alterations following absence seizures in a rat model of GRIN2B neurodevelopmental disorder

Zita Francsics, Eleni Tsoukala, Katerina Hristova, Alfredo Gonzalez-Sulser & Lida Zoupi – (2025) Brain and Neuroscience Advances  (doi: 10.1177/23982128251405032)

The LncRNA MYRACL Regulates Human Oligodendrocyte Maturation and Myelination.

Themistoklis M. Tsarouchas, Francesca Vacante, Nina-Lydia Kazakou, Laura Wagstaff, Matthew Bennett, Lida Zoupi, Erin M. Gibson, Andrew H. Baker & Anna Williams – (2025) Molecular Therapy  (doi : 10.1016/j.ymthe.2025.08.011)

The Fragile X Messenger Ribonucleoprotein 1 regulates the morphology and maturation of human and rat oligodendrocytes

Vidya Ramesh, Eleni Tsoukala, Ioanna Kougianou, Zrinko Kozic, Karen Burr, Biju Viswanath, David Hampton, David Story, Bharath Kumar Reddy, Rakhi Pal, Owen Dando, Peter C. Kind, Sumantra Chattarji, Bhuvaneish T Selvaraj, Siddharthan Chandran and Lida Zoupi – (2025)  GLIA & bioRxiv (doi:  10.1002/glia.24680)

Protocol for assessing myelination by human iPSC-derived oligodendrocytes in Shiverer mouse ex vivo brain slice cultures

Themistoklis M. Tsarouchas, Lida Zoupi, Anna Williams & Erin M. Gibson – (2025) STAR Protocols  (doi: 10.1016/j.xpro.2025.103609)

PUFFFIN: an ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods

Tamina Lebek, Mattias Malaguti, Giulia LM Boezio, Lida Zoupi, James Briscoe, Alistair Elfick & Sally Lowell – (2024) EMBO Journal  (doi: 10.1038/s44318-024-00154-w)

Editorial: Molecular and cellular interactions of myelin in neurodevelopmental & neurodegenerative disorders

Paschalis Theotokis, Lida Zoupi, Marie-Ève Tremblay, Jing-Wei Zhao – (2023) Frontiers in Cellular Neuroscience  (doi: 10.3389/fncel.2023.1359184)

Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination

Amina Zahaf, Abdelmoumen Kassoussi, Tom Hutteau-Hamel, Amine Mellouk, Corentine Marie, Lida Zoupi, Foteini Tsouki, Claudia Mattern, Pierre Bobé, Michael Schumacher, Anna Williams, Carlos Parras & Elisabeth Traiffort- (2023)  Nature Communications (doi: 10.1038/s41467-023-36846-w)

Origin and Emergence of Microglia in the CNS – An Interesting (Hi)story of an Eccentric Cell

Iasonas Dermitzakis, Maria Eleni Manthou, Soultana Meditskou, Marie-Ève Tremblay, Steven Petratos, Lida Zoupi, Marina Boziki, Evangelia Kesidou, Constantina Simeonidou & Paschalis Theotokis –  (2023) CIMB  (doi: 10.3390/cimb45030171)

Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with age

Cody L. Call, Sarah A. Neely, Jason J. Early, Owen G. James, Lida Zoupi, Anna C. Williams, Siddharthan Chandran, David A. Lyons & E. Bergles – (2022) PREPRINT 

New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Sarah A. Neely, Jill M. Williamson, Anna Klingseisen, Lida Zoupi, Jason J. Early, Anna Williams & David A. Lyons – (2022) Nature Neuroscience & bioRxiv (doi: 10.1101/2020.05.22.110551)

Selective vulnerability of inhibitory networks in multiple sclerosis

Lida Zoupi, Sam A. Booker, Dimitri Eigel, Carsten Werner, Peter C. Kind, Tara L. Spires-Jones, Ben Newland & Anna C. Williams – (2021) Acta Neuropathologica

Cryogel scaffolds for regionally constrained delivery of lysophosphatidylcholine to central nervous system slice cultures: A model of focal demyelination for multiple sclerosis research

Dimitri Eigel, Lida Zoupi, Sowmya Sekizar, Petra B. Welzel, Carsten Werner, Anna Williams & Ben Newland – (2019) Acta Biomaterialia

Alkyne-tagged PLGA allows direct visualisation of nanoparticles in vitro and ex vivo by stimulated Raman scattering microscopy

Sally Vanden-Hehir, Stefan A. Cairns, Martin Lee, Lida Zoupi, Michael P. Shaver, Valerie G. Brunton, Anna Williams & Alison N. Hulme – (2019) Biomacromolecules

The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex

Ana M. Meireles, Kimberle Shen, Lida Zoupi, Harini Iyer, Ellen L. Bouchard, Anna Williams & William S. Talbot – (2018) Developmental Cell

The function of contactin-2/TAG-1 in oligodendrocytes in health and demyelinating pathology

Lida Zoupi, Maria Savvaki, Katerina Kalemaki, Ilias Kalafatakis, Kyriaki Sidiropoulou & Domna Karagogeos – (2018) GLIA

Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis

Delphine Pinatel, Bruno Hivert, José Boucraut, Margaux Saint-Martin, Véronique Rogemond, Lida Zoupi, Domna Karagogeos, Jérôme Honnorat & Catherine Faivre-Sarrailh – (2015) Frontiers in Cellular Neuroscience

Alterations of juxtaparanodal domains in two rodent models of CNS demyelination

Lida Zoupi, Kyriaki Markoullis, Kleopas A. Kleopa & Domna Karagogeos – (2013) GLIA

Axons and myelinating glia: An intimate contact

Lida Zoupi, Maria Savvaki & Domna Karagogeos – (2011) IUBMB life

The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of tag-1 homozygous mutants in the CNS

Maria Savvaki, Kostas Theodorakis, Lida Zoupi, Antonis Stamatakis, Simona Tivodar, Kyriacos Kyriacou, Fotini Stylianopoulou & Domna Karagogeos – (2010) The Journal of Neuroscience