We are investigating how myelination affects network function in health and in neurodevelopmental disorders. Myelination, the formation of multi-layered membrane sheaths around axons is critical for neuronal health and fast signal transmission. In the central nervous system, myelin is produced by glia cells called oligodendrocytes. Each oligodendrocyte extends multiple processes that wrap around different axons, providing electrical insulation and metabolic support. Our goal is to explore the communication between neurons and oligodendrocytes during brain development, with the hope to reveal new strategies for cellular and functional recovery in neurodevelopmental disorders.